A 39-year-old man who has sex with men and who recently had multiple new, anonymous sex partners presents to clinic. He was last tested for HIV two years ago. He last had condomless rectal sex 14 days ago. He reports recent fevers, sore throat, swollen lymph nodes, and a faint rash. His clinician orders an HIV RNA test plus an HIV antigen-antibody immunoassay.
Which one of the following is TRUE regarding plasma HIV-1 RNA tests?

Figure 1. HIV Assay Test Reactivity after Initial Acquisition of HIV
This illustration represents timing of HIV testing becoming positive following HIV acquisition.
Source: modified from Centers for Disease Control and Prevention and Association of Public Health Laboratories. Laboratory Testing for the Diagnosis of HIV Infection: Updated Recommendations. Published June 27, 2014. Abbreviation: POC = point of care
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Question Last Updated
February 1st, 2025
February 1st, 2025
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