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Lesson 5. Hepatitis B Coinfection

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Hepatitis B Coinfection Overview

About this Lesson

Last Updated: February 3rd, 2025

CNE/CME Continuing Education

This lesson qualifies for:

1.5 CME AMA PRA Category 1 Credits™, or
1.5 CNE contact hours and 1.5 CE contact hours (qualifies for pharmacology CE for advanced practice nurses)

CNE and CME Origination: October 1st, 2017

CNE and CME Review: September 1st, 2023

CNE and CME Expiration: August 31st, 2026 (3rd Edition)

Steps to Acquire CE for this Lesson:

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Quiz

Score 80%+

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3rd Edition

This is a substantial revision of the original Lesson. The previous edition was titled Hepatitis B Coinfection and available until September 1st, 2023.

Learning Objectives

Identify appropriate tests for evaluation of hepatitis B virus (HBV) infection and immunity
Summarize the approach to persons with HIV who have isolated hepatitis B core antibody
Discuss antiretroviral management of persons with HIV and HBV coinfection
Describe HBV-related immune reconstitution syndrome
List indications and methods for hepatocellular carcinoma surveillance in persons with chronic HBV and HIV coinfection

Lesson Contributors

Authors

H. Nina Kim, MD, MSc

H. Nina Kim, MD, MSc
Professor of Medicine
Division of Allergy & Infectious Diseases
University of Washington

Disclosures:

None

David H. Spach, MD

David H. Spach, MD
Professor of Medicine
Division of Allergy & Infectious Diseases
University of Washington

Disclosures:

None

Reviewers

Aley G. Kalapila, MD, PhD

Aley G. Kalapila, MD, PhD
Associate Professor of Medicine
Division of Infectious Diseases
Emory University School of Medicine
Grady Health System

Disclosures:

None

Lesson Plan

1Topic 1 Background

2Topic 2 Screening for HBV in Persons with HIV

3Topic 3 Initial Evaluation of Persons with HBV and HIV Coinfection

4Topic 4 Treatment of HBV and HIV in Persons with HIV and HBV Coinfection

5Topic 5 Monitoring HBV Treatment Response

6Topic 6 Management of HIV or HBV Virologic Failure

7Topic 7 Stopping HBV Treatment and Hepatic Flares

8Topic 8 HBV-Related Immune Reconstitution Syndrome (HBV-IRIS)

9Topic 9 Hepatitis D Virus

10Topic 10 Preventing HBV Perinatal Transmission

11Topic 11 Surveillance for Hepatocellular Carcinoma

12Topic 12 Managing Persons with Coinfection and Advanced Liver Disease

13Topic 13 Summary Points

Lesson Quiz Hepatitis B Coinfection Quiz

Survey Lesson Survey

The National HIV Curriculum is supported by the Health Resources and Services Administration (HRSA) of the U.S. Department of Health and Human Services (HHS) as part of a financial assistance award totaling $1,172,990 with 0% financed with non-governmental sources. The contents are those of the author(s) and do not necessarily represent the official views of, nor an endorsement, by HRSA, HHS, or the U.S. Government. For more information, please visit HRSA.gov. This project is led by the University of Washington Infectious Diseases Education and Assessment (IDEA) Program.

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