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Apply Evidence-Based Recommendations for the Prevention of HIV Transmission

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Lesson 5. HIV Preexposure Prophylaxis (PrEP)

Apply Evidence-Based Recommendations for the Prevention of HIV Transmission

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HIV Preexposure Prophylaxis (PrEP) Overview

About this Lesson

Last Updated: December 22nd, 2023

CNE/CME Continuing Education

This lesson qualifies for:

2 CME AMA PRA Category 1 Credits™, or
2 CNE contact hours and 2 CE contact hours (qualifies for pharmacology CE for advanced practice nurses)

CNE and CME Origination: July 1st, 2017

CNE and CME Review: September 1st, 2023

CNE and CME Expiration: August 31st, 2026 (3rd Edition)

Steps to Acquire CE for this Lesson:

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Quiz

Score 80%+

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3rd Edition

This is a substantial revision of the original Lesson. The previous edition was titled HIV Preexposure Prophylaxis (PrEP) and available until September 1st, 2023.

Learning Objectives

List persons to consider who may benefit from HIV PrEP
Explain recommendations for testing and counseling prior to starting PrEP
Discuss the recommended PrEP regimens, including dosing, safety, efficacy, and clinical eligibility
Describe recommended clinical and laboratory baseline evaluation and monitoring for persons receiving HIV PrEP
Summarize initial management of persons who develop HIV while receiving HIV PrEP

Lesson Contributors

Authors

David H. Spach, MD

David H. Spach, MD
Professor of Medicine
Division of Allergy & Infectious Diseases
University of Washington

Disclosures:

None

Aley G. Kalapila, MD, PhD

Aley G. Kalapila, MD, PhD
Associate Professor of Medicine
Division of Infectious Diseases
Emory University School of Medicine
Grady Health System

Disclosures:

None

Reviewers

Brian R. Wood, MD

Brian R. Wood, MD
Professor of Medicine
Division of Allergy & Infectious Diseases
University of Washington

Disclosures:

None

Lesson Plan

1Topic 1 Introduction

2Topic 2 Persons to Consider for HIV PrEP

3Topic 3 Recommended Regimens and Dosing for HIV PrEP

4Topic 4 Baseline Laboratory Evaluation, Immunizations, and Counseling

5Topic 5 Major HIV PrEP Studies

6Topic 6 Time to Achieve Protection after Initiating HIV PrEP

7Topic 7 Impact of Adherence on Efficacy of HIV PrEP

8Topic 8 Laboratory Monitoring on HIV PrEP

9Topic 9 Acquisition of HIV in the Setting of HIV PrEP

10Topic 10 HIV PrEP and Development of HIV Drug Resistance

11Topic 11 Adverse Effects of Medications Used for HIV PrEP

12Topic 12 Changes in Sexual Practices Among Persons Receiving HIV PrEP

13Topic 13 Discontinuing PrEP

14Topic 14 Transitioning from Nonoccupational HIV PEP to HIV PrEP

15Topic 15 HIV PrEP Uptake

16Topic 16 Future HIV PrEP Medications

17Topic 17 Summary Points

Lesson Quiz HIV Preexposure Prophylaxis (PrEP) Quiz

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The National HIV Curriculum is supported by the Health Resources and Services Administration (HRSA) of the U.S. Department of Health and Human Services (HHS) as part of a financial assistance award totaling $1,172,990 with 0% financed with non-governmental sources. The contents are those of the author(s) and do not necessarily represent the official views of, nor an endorsement, by HRSA, HHS, or the U.S. Government. For more information, please visit HRSA.gov. This project is led by the University of Washington Infectious Diseases Education and Assessment (IDEA) Program.

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