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Co-Occurring Conditions Overview3rd Edition

Module Core Competency

Apply Evidence-Based Recommendations for the Evaluation and Management of Co-Occurring Conditions in Persons with HIV Infection

Target Audience

Examine how to prevent and treat common opportunistic infections in people with HIV before delving into how to screen and treat sexually transmitted infections, latent tuberculosis, hepatitis C, and hepatitis B.

Editor

David H. Spach, MD

David H. Spach, MD
Professor of Medicine
Division of Allergy & Infectious Diseases
University of Washington

Disclosures: None

1Lesson 1 Latent Tuberculosis Infection

Learning Objectives
- Discuss the epidemiology of tuberculosis and HIV coinfection in the United States
- State the rationale for screening for latent TB in people with HIV
- Describe and compare recommended screening tests for latent TB in people with HIV
- List recommended options for the treatment of latent TB in people with HIV
- Summarize common drug interactions between medications used to treat latent TB and common antiretroviral medications
Quick ReferenceLatent Tuberculosis Infection Core Concepts

2Lesson 2 Opportunistic Infections: Prevention

Learning Objectives
- Discuss recommendations for initiating primary prevention of opportunistic infections in people with HIV
- Summarize recommendations for initiating secondary prophylaxis of opportunistic infections in people with HIV
- State criteria for discontinuing primary prevention of opportunistic infections in people with HIV
- List criteria for discontinuing secondary prophylaxis of opportunistic infections in people with HIV
- Recognize potential adverse effects and contraindications for medications used for prevention of opportunistic infections
Quick ReferenceOpportunistic Infections: Prevention Core Concepts

3Lesson 3 Opportunistic Infections: Treatment

Learning Objectives
- Describe trends in the incidence of opportunistic infections in people with HIV
- Recognize the clinical manifestations of common serious opportunistic infections that occur in people with HIV
- Discuss recommended treatment of common opportunistic infections
- List indications for discontinuing treatment for opportunistic infections
- Summarize recommendations for initiating antiretroviral therapy in the setting of an active opportunistic infection
Quick ReferenceOpportunistic Infections: Treatment Core Concepts

4Lesson 4 Sexually Transmitted Infections

Learning Objectives
- Describe the recommendations for sexually transmitted infection screening in people with HIV
- Summarize CDC recommendations for the treatment of common sexually transmitted infections in people with HIV
- Explain the different stages of syphilis and the recommended treatments at each stage
- Discuss laboratory-based methods for diagnosing syphilis
- List recommended treatment and suppressive treatment options for genital herpes in people with HIV
Quick ReferenceSexually Transmitted Infections Core Concepts

5Lesson 5 Hepatitis B Coinfection

Learning Objectives
- Identify appropriate tests for evaluation of hepatitis B virus (HBV) infection and immunity
- Summarize the approach to persons with HIV who have isolated hepatitis B core antibody
- Discuss antiretroviral management of persons with HIV and HBV coinfection
- Describe HBV-related immune reconstitution syndrome
- List indications and methods for hepatocellular carcinoma surveillance in persons with chronic HBV and HIV coinfection
Quick ReferenceHepatitis B Coinfection Core Concepts
Activity 5B.Hepatitis Delta Infection

6Lesson 6 Hepatitis C Coinfection

Learning Objectives
- Explain recommendations for HCV screening in people with HIV
- Describe the appropriate HCV testing algorithm
- Summarize the eligibility criteria and current guidelines for the simplified HCV treatment in people with HIV
- Discuss simplified HCV treatment regimens options for people with HIV
- List indications and methods for hepatocellular carcinoma surveillance in persons with chronic HCV and HIV
Quick ReferenceHepatitis C Coinfection Core Concepts

The Check-on-Learning Questions are short and topic related. They are meant to help you stay on track throughout each lesson and check your understanding of key concepts.

Screening and Diagnosis

Basic HIV Primary Care

Antiretroviral Therapy