A 31-year-old man with a new diagnosis of HIV presents for an initial evaluation visit. White plaques are noted on the lateral aspects of the tongue and do not scrape off (Figure 1). The initial CD4 count is 78 cells/mm3. He has never been a smoker.
Which one of the following is the most likely cause of this condition?

Figure 1. White Plaques on Lateral Region of Tongue
Source: Photograph from David H. Spach, MD

Figure 2. Oral Hairy Leukoplakia
The white plaques on the lateral aspect of the tongue were not removed by scraping with a tongue-blade.
Source: Photograph from David H. Spach, MD

Figure 3. Oral Hairy Leukoplakia on Lateral Tongue
Photograph courtesy of Mark Nichols, DDS, Dental Director, South Central AETC
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Question Last Updated
January 28th, 2025
January 28th, 2025
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