A 55-year-old man with extensive drug-resistant HIV returns to the clinic for a routine follow-up appointment and reports recent weight gain, weakness in his legs, easy bruising, and changes in mood (anxiety and agitation). Laboratory studies performed 1 week prior revealed an undetectable HIV RNA level, a CD4 count of 314 cells/mm³, and elevated blood glucose of 168 gm/dL. Seven months ago, the patient was started on an antiretroviral regimen of once-daily tenofovir alafenamide-emtricitabine, doravirine, twice-daily dolutegravir, twice-daily darunavir, and twice-daily ritonavir. He also takes atorvastatin 10 mg daily, loratadine 10 mg once daily, and fluticasone nasal spray, 2 sprays in each nostril once daily. His physical examination in the office today shows an elevated blood pressure of 168/98 mmHg, an enlarged central abdominal region, and multiple bruises, predominantly on the arms.