A 64-year-old cisgender man has an extensive past history of taking antiretroviral medications, including 2 years of zidovudine monotherapy, 1 year of zidovudine-lamivudine, and 3 years of stavudine, lamivudine, and indinavir. For the past 4 years, he has maintained virologic suppression on a regimen of darunavir-cobicistat, fostemsavir, and maraviroc. The clinical notes in his chart repeatedly state that his genotype shows thymidine analog mutations (TAMs).
Which one of the following best defines the group of mutations known as thymidine analog mutations (TAMs)?
Figure 1. Thymidine Analog Mutations (TAMs)
Illustration by David H. Spach, MD
Figure 2. Mechanism of Resistance Mechanisms Associated with TAM Mutations
Source: Illustration by David H. Spach, MD
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Question Last Updated
September 21st, 2023
September 21st, 2023
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