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Antiretroviral Therapy.

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Evaluation and Management of Virologic FailureQuestion 2/10

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A 37-year-old woman with HIV returns to clinic after being out of care for several years. Previously, she received a regimen of boosted atazanavir with tenofovir DF-emtricitabine, but experienced virologic breakthrough (HIV RNA 2,980 copies/mL). A genotype was performed at the time and showed only a reverse transcriptase M184V mutation.

Which one of the following statements is TRUE regarding the M184V mutation?

This graphic illustration shows the impact of the M184V mutation on nucleoside reverse transcriptase inhibitors (NRTIs) based on the Stanford University HIV Drug Resistance Database mutation scoring for the M184V mutation.
Figure 1. Impact of M184V Mutation on Nucleoside Reverse Transcriptase Inhibitors (NRTIs)
This graphic illustration shows the impact of the M184V mutation on nucleoside reverse transcriptase inhibitors (NRTIs) based on the Stanford University HIV Drug Resistance Database mutation scoring for the M184V mutation.
Stanford University HIV Drug Resistance Database
Illustration: David H. Spach, MD
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Question Last Updated
February 1st, 2025

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