Sign In

Screening and Diagnosis.

HIV Question Bank

Acute and Recent HIV InfectionQuestion 1/10

Questions in Topic

Which one of the following describes the typical initial infection event that occurs with sexual transmission of HIV-1?

This image shows multiple HIV particles approaching the mucosal surface, but only one virus sustaining replication. This virus, shown as the purple virion, is known as the 'founder virus'. Following the transmitter/founder virus infection, the initial local replication of HIV consists of a relatively homogenous population of virions.
Figure 1. Founder Virus and HIV Infection
This image shows multiple HIV particles approaching the mucosal surface, but only one virus sustaining replication. This virus, shown as the purple virion, is known as the 'founder virus'. Following the transmitter/founder virus infection, the initial local replication of HIV consists of a relatively homogenous population of virions.
Source: Keele BF, Giorgi EE, Salazar-Gonzalez JF, et al. Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infection. Proc Natl Acad Sci U S A. 2008;105:7552-7.
Illustration: David H. Spach, MD
With acute HIV, the type of HIV that is transmitted is almost always R5 HIV (as opposed to X4 HIV). The R5 HIV strains first attach to the host CD4 receptor and then bind to the CCR5 coreptor.
Figure 2. R5-Tropic HIV and Host Coreceptor Binding
With acute HIV, the type of HIV that is transmitted is almost always R5 HIV (as opposed to X4 HIV). The R5 HIV strains first attach to the host CD4 receptor and then bind to the CCR5 coreptor.
Illustration: David H. Spach, MD
Prev  Skip

Sign In or Register Progress Not Saved!
Since you are not signed in, your progress won't be saved.
Question Last Updated
January 28th, 2025

Steps to Acquire CE for this Question Bank Topic:

1

Answer

Answer all questions
2

Score 80%+

Answer correctly
3

Claim CE

Choose CNE or CME
4

Give Feedback

Complete survey
5

Print Certificate

Obtain proof of CE

This question requires improvement because:


Comment further on how to improve this question or summary:



Since you've received 80% or better on this quiz, you may claim continuing education credit.

You seem to have a popup blocker enabled. If you want to skip this dialog please Always allow popup windows for the online course.