A 31-year-old pregnant cisgender woman who is in the first trimester of pregnancy presents to urgent care with 3 days of fever, headache, muscle aches, and a diffuse erythematous rash. She is noted to have cervical and axillary lymphadenopathy. She reports condomless sex approximately 3 weeks ago with a new male partner. There is clinical suspicion for acute HIV. The HIV-1/2 antigen-antibody immunoassay is positive, the HIV-1/HIV-2 antibody differentiation immunoassay is negative, and the quantitative HIV RNA is positive with a level of 688,512 copies/mL. A diagnosis of acute HIV is made, and an HIV drug resistance genotype is ordered. She has never received HIV preexposure prophylaxis (PrEP).