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HIV Preexposure Prophylaxis (PrEP)Question 2/10

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A 30-year-old cisgender man who has sex with men is seen in a clinic with the plan to start HIV preexposure prophylaxis (PrEP). His last sexual encounter was 3 weeks ago. He prefers taking daily oral medication for HIV PrEP, and the plan is to use daily oral tenofovir alafenamide-emtricitabine. He has never received HIV preexposure prophylaxis or HIV postexposure prophylaxis.

In addition to performing standard screening for sexually transmitted infections, what baseline laboratory studies should be performed prior to starting tenofovir alafenamide-emtricitabine as HIV PrEP?

Note: Although hepatitis B serology is not required for persons starting injectable cabotegravir, many experts would obtain hepatitis B serology to to identify nonimmune persons who can receive hepatitis B immunization. For persons initiating cabotegravir for PrEP, screening for HIV should occur prior to the oral cabotegravir lead in (if used) and prior to the first cabotegravir injection.<br /> Abbreviations: eCrCL = estimated creatinine clearance; MSM = men who have sex with men; TGW = transgender women; PWID = persons who inject drugs
Figure 1. Recommended Baseline Laboratory Studies in Persons Starting HIV PrEP
Note: Although hepatitis B serology is not required for persons starting injectable cabotegravir, many experts would obtain hepatitis B serology to to identify nonimmune persons who can receive hepatitis B immunization. For persons initiating cabotegravir for PrEP, screening for HIV should occur prior to the oral cabotegravir lead in (if used) and prior to the first cabotegravir injection.
Abbreviations: eCrCL = estimated creatinine clearance; MSM = men who have sex with men; TGW = transgender women; PWID = persons who inject drugs
Siource: Centers for Disease Control and Prevention: US Public Health Service: Preexposure prophylaxis for the prevention of HIV infection in the United States—2021 Update: a clinical practice guideline. December 2021:1-108.
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Question Last Updated
September 20th, 2023

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