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HIV Preexposure Prophylaxis (PrEP)Question 10/10

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A 25-year-old cisgender man who has sex with men presents for evaluation to start HIV preexposure prophylaxis (PrEP). He is interested in HIV PrEP but does not believe he would reliably take a pill every day. He states that he typically knows when he is likely to have sex, it does not occur more than a couple of times per month, and he says he can follow a schedule for taking pills before and after sex.

Which one of the following is the recommended dosing schedule for “on-demand” or “2-1-1” tenofovir DF-emtricitabine for HIV PrEP?

Figure 1. On Demand (2-1-1) Oral HIV Preexposure Prophylaxis
Illustration: David H. Spach, MD
Note: if sexual activity continues for multiple consecutive days, the 
Figure 2. On Demand (2-1-1) Oral HIV Preexposure Prophylaxis with Continued Sexual Activity
Note: if sexual activity continues for multiple consecutive days, the 
Illustration: David H. Spach, MD
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Question Last Updated
September 20th, 2023

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