A 55-year-old cisgender man is seen in clinic for a routine follow-up visit and he would like to address side effects he is experiencing with his antiretroviral medications. Several years ago, he started on a regimen of darunavir boosted with ritonavir plus tenofovir DF-emtricitabine. His baseline HIV with drug resistance genotype showed only an M184V mutation. He has consistently had suppressed HIV RNA levels on this regimen, but in the last 6 months, he has developed gastrointestinal symptoms related to his medications. In addition, he has a new work schedule and is having difficulty taking his antiretroviral medications consistently with food. He would like to take a single-tablet regimen that does not have food restrictions. A previous  HLA-B*5701 test was negative.