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Doravirine-Tenofovir DF-Lamivudine (Delstrigo)
Other Names: DOR-TDF-3TC, Doravirine-Tenofovir disoproxil fumarate-LamivudineAll Clinical Trials
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Official Title A Phase III Multicenter, Double-Blind, Randomized, Active Comparator-Controlled Clinical Trial to Evaluate the Safety and Efficacy of Fixed-dose Combination Doravirine-Tenofovir disoproxil fumarate-Lamivudine (MK-1439A) Once-Daily Versus ATRIPLA™ Once-Daily in Treatment-Naïve HIV-1 Infected Subjects
Phase Phase III
ClinicalTrials.gov NCT02403674
Treatments
Doravirine
, Doravirine
Tradename:PifeltroOther Names:DORClass:Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTI)Doravirine-Tenofovir DF-Lamivudine
Doravirine-Tenofovir DF-Lamivudine
Tradename:DelstrigoOther Names:DOR-TDF-3TC, Doravirine-Tenofovir disoproxil fumarate-LamivudineClass:Single-Tablet RegimensCategories Treatment-Naive
Funding
IndustryMerck
References
- Orkin C, Squires KE, Molina JM, et al. Doravirine/Lamivudine/Tenofovir Disoproxil Fumarate is Non-inferior to Efavirenz/Emtricitabine/Tenofovir Disoproxil Fumarate in Treatment-naive Adults With Human Immunodeficiency Virus-1 Infection: Week 48 Results of the DRIVE-AHEAD Trial. Clin Infect Dis. 2019;68:535-44.
Official Title A Phase III Multicenter, Open-Label, Randomized Study to Evaluate a Switch to doravirine plus lamivudine plus tenofovir disoproxil fumarate in HIV-1-Infected Subjects Virologically Suppressed on a Regimen of a Ritonavir-boosted Protease Inhibitor and Two Nucleoside Reverse Transcriptase Inhibitors (NRTIs)
Phase Phase III
ClinicalTrials.gov NCT02397096
Treatments
Doravirine
, Doravirine
Tradename:PifeltroOther Names:DORClass:Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTI)Doravirine-Tenofovir DF-Lamivudine
Doravirine-Tenofovir DF-Lamivudine
Tradename:DelstrigoOther Names:DOR-TDF-3TC, Doravirine-Tenofovir disoproxil fumarate-LamivudineClass:Single-Tablet RegimensCategories Treatment-ExperiencedSwitch/Simplification
Funding
IndustryMerck Sharp & Dohme Corp
References
- Johnson M, Kumar P, Molina JM, et al. Switching to Doravirine/Lamivudine/Tenofovir Disoproxil Fumarate (DOR/3TC/TDF) Maintains HIV-1 Virologic Suppression Through 48 Weeks: Results of the DRIVE-SHIFT Trial. J Acquir Immune Defic Syndr. 2019;81:463-72.
Common TitleDRIVE BEYOND Industry
Official Title A Phase IIa Multicenter, Open-Label Clinical Trial to Evaluate the Safety and Efficacy of Doravirine-Tenofovir disoproxil fumarate-Lamivudine (MK-1439A) in Treatment-Naïve HIV-1 Infected Subjects With Selected Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI) Transmitted Resistance Mutations
Phase Phase IIA
ClinicalTrials.gov NCT02629822
Treatments
Doravirine-Tenofovir DF-Lamivudine
Doravirine-Tenofovir DF-Lamivudine
Tradename:DelstrigoOther Names:DOR-TDF-3TC, Doravirine-Tenofovir disoproxil fumarate-LamivudineClass:Single-Tablet RegimensFunding
IndustryMerck
References
No references available for this clinical trial
Common TitleMK-1439A-028 Industry
Official Title Phase IIb, Double-Blinded, Multicenter, Randomized Study to Assess the Effect on Central Nervous System (CNS) Toxicity of Switching From ATRIPLA™ (Efavirenz, Tenofovir, Emtricitabine) to MK-1439A (Doravirine, Tenofovir, Lamivudine) in Virologically-Suppressed Subjects.
Phase Phase IIB
ClinicalTrials.gov NCT02652260
Treatments
Doravirine
, Doravirine
Tradename:PifeltroOther Names:DORClass:Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTI)Doravirine-Tenofovir DF-Lamivudine
Doravirine-Tenofovir DF-Lamivudine
Tradename:DelstrigoOther Names:DOR-TDF-3TC, Doravirine-Tenofovir disoproxil fumarate-LamivudineClass:Single-Tablet RegimensFunding
IndustryMerck
References
No references available for this clinical trial
Doravirine-Tenofovir DF-Lamivudine Slide Deck
Clinical Trial Image Decks
DRIVE AHEAD - November 25, 2022
DRIVE SHIFT - November 25, 2022