A 31-year-old pregnant cisgender woman from Senegal undergoes routine HIV testing. The HIV-1/2 antigen-antibody immunoassay test is positive. You are concerned she may have HIV-2 and plan to specifically test for HIV-2.
Which one of the following is an appropriate test for differentiating HIV-1 from HIV-2 in this woman?
Figure 1. Geenius HIV-1/HIV-2 Supplemental Assay
Source: modified from Fernández McPhee C, Álvarez P, Prieto L, et al. HIV-1 infection using dried blood spots can be confirmed by Bio-Rad Geenius™ HIV 1/2 confirmatory assay. J Clin Virol. 2015;63:66-9.
Figure 2. 2018 CDC AHPL Recommended Laboratory HIV Testing Algorithm for Serum or Plasma Specimens
Source: (1) Centers for Disease Control and Prevention and Association of Public Health Laboratories. Laboratory Testing for the Diagnosis of HIV Infection: Updated Recommendations. Published June 27, 2014. (2) Centers for Disease Control and Prevention and Association of Public Health Laboratories. 2018 Quick reference guide: Recommended laboratory HIV testing algorithm for serum or plasma specimens. Published January 27, 2018.
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Question Last Updated
September 27th, 2023
September 27th, 2023
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