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A 31-year-old pregnant woman from Senegal undergoes routine HIV testing. The HIV-1/2 antigen-antibody immunoassay test is positive. You are concerned she may have HIV-2 and plan to specifically test for HIV-2.

Which one of the following is an appropriate test for differentiating HIV-1 from HIV-2 in this woman?

The Geenius HIV-1/HIV-2 Supplemental Assay is a single-use immunochromatographic test that utilizes multiple recombinant or synthetic peptides to detect HIV-1 and HIV-2. Note the HIV-2 antibodies detected include gp36 and gp140 (marked by yellow color).
Figure 1. Geenius HIV-1/HIV-2 Supplemental Assay
The Geenius HIV-1/HIV-2 Supplemental Assay is a single-use immunochromatographic test that utilizes multiple recombinant or synthetic peptides to detect HIV-1 and HIV-2. Note the HIV-2 antibodies detected include gp36 and gp140 (marked by yellow color).
Source: modified from Fernández McPhee C, Álvarez P, Prieto L, et al. HIV-1 infection using dried blood spots can be confirmed by Bio-Rad Geenius™ HIV 1/2 confirmatory assay. J Clin Virol. 2015;63:66-9.
This graphic shows the HIV testing algorithm as recommended in 2014 and updated in 2018 by the Centers for Disease Control and Prevention and Association of Public Health Laboratories.
Figure 2. 2018 CDC AHPL Recommended Laboratory HIV Testing Algorithm for Serum or Plasma Specimens
This graphic shows the HIV testing algorithm as recommended in 2014 and updated in 2018 by the Centers for Disease Control and Prevention and Association of Public Health Laboratories.
Source: (1) Centers for Disease Control and Prevention and Association of Public Health Laboratories. Laboratory Testing for the Diagnosis of HIV Infection: Updated Recommendations. Published June 27, 2014. (2) Centers for Disease Control and Prevention and Association of Public Health Laboratories. 2018 Quick reference guide: Recommended laboratory HIV testing algorithm for serum or plasma specimens. Published January 27, 2018.
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Question Last Updated
February 2nd, 2025

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