A 58-year-old cisgender man with HIV and chronic hepatitis B virus (HBV) coinfection has been taking dolutegravir and tenofovir DF-emtricitabine for approximately 4 years with suppressed HIV RNA and HBV DNA levels. Laboratory studies performed 4 months ago showed a CD4 count of 610 cells/mm3 and alanine aminotransferase (ALT) level of 22 U/L. At the visit today, he informs you he stopped taking the antiretroviral medications about 7 weeks ago because he could not afford the medication copayments. For the past 75 days, he has experienced fatigue, nausea, and right upper quadrant pain. His laboratory studies show an ALT level of 465 U/L, HBV DNA level of 880,500 IU/mL, and HIV RNA level of 17,900 copies/mL.
Which one of the following would you recommend to address the hepatitis flare?
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Question Last Updated
September 29th, 2023
September 29th, 2023
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