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Antiretroviral Therapy.

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Adverse Effects of Antiretroviral MedicationsQuestion 6/10

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A 50-year-old transgender woman with multidrug-resistant HIV started a new salvage antiretroviral therapy regimen 8 weeks ago that consisted of darunavir plus ritonavir, dolutegravir, tenofovir alafenamide-emtricitabine, and doravirine. Her serum creatinine has risen from a baseline level of 0.9 mg/dL to 1.1 mg/dL. There is no proteinuria. A recheck of the serum creatinine during the next 9 months shows it is stable at 1.1 to 1.2 mg/dL.

Which one of the following antiretroviral medications is the likely cause for the increase in serum creatinine?

Figure 1. Inhibiition of Tubular Creatinine Secretion by Bictegravir and Dolutegravir
Illustration: David H. Spach, MD
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Question Last Updated
July 27th, 2024

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