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Common TitleSOLAR
Official Title A Phase IIIb, Randomized, Multicenter, Active-controlled, Parallel-group, Non-inferiority, Open-label Study Evaluating the Efficacy, Safety, and Tolerability of Switching to Long-acting Cabotegravir Plus Long-acting Rilpivirine Administered Every Two Months From a Bictegravir/Emtricitabine/Tenofovir Alafenamide Single Tablet Regimen in HIV-1 Infected Adults Who Are Virologically Suppressed
Purpose / DescriptionThis study is designed to assess the antiviral activity and safety of a two-drug regimen of CAB LA + RPV LA compared with maintenance of BIK. BIKTARVY is a registered trademark of Gilead Sciences.
Phase Phase IIIB
ClinicalTrials.gov NCT04542070
Treatments
Injectable cabotegravir and Rilpivirine

Injectable cabotegravir and Rilpivirine

Tradename:CabenuvaClass:Long-Acting Injectable Regimens
Categories Treatment-ExperiencedSwitch/Simplification
Funding
IndustryViiV Healthcare
References
  • Ramgopal MN, Castagna A, Cazanave C, et al. Efficacy, safety, and tolerability of switching to long-acting cabotegravir plus rilpivirine versus continuing fixed-dose bictegravir, emtricitabine, and tenofovir alafenamide in virologically suppressed adults with HIV, 12-month results (SOLAR): a randomised, open-label, phase 3b, non-inferiority trial. Lancet HIV. 2023;10:e566-e577.
    [PubMed Abstract]

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