Common TitleSWEET
Official Title A Phase 3, Open Label, Randomised, Parallel Group Study to Compare the Effect on Prevention and Resolution of Treatment Related Adverse Events of a Simplified, Once Daily Regimen of a Fixed Dose Combination Tablet of Emtricitabine and Tenofovir DF Versus Twice Daily co-Formulated Zidovudine and Lamivudine (Combivir®) or Zidovudine and Lamivudine, in Virologically Suppressed, HIV Infected Patients Taking Efavirenz
Phase Phase III
ClinicalTrials.gov NCT00323544
Treatments
Tenofovir DF-Emtricitabine![Tenofovir DF-Emtricitabine Truvada and Multiple Generics](https://cdn.hiv.uw.edu/css/images/drugs/35.png)
, ![Tenofovir DF-Emtricitabine Truvada and Multiple Generics](https://cdn.hiv.uw.edu/css/images/drugs/35.png)
Tenofovir DF-Emtricitabine
Tradename:Truvada and Multiple GenericsOther Names:TDF-FTC, Tenofovir disoproxil fumarate-EmtricitabineClass:Nucleoside Reverse Transcriptase Inhibitors (NRTI)Zidovudine-Lamivudine![Zidovudine-Lamivudine Combivir](https://cdn.hiv.uw.edu/css/images/drugs/37.png)
, ![Zidovudine-Lamivudine Combivir](https://cdn.hiv.uw.edu/css/images/drugs/37.png)
Zidovudine-Lamivudine
Tradename:CombivirOther Names:ZDV-3TCClass:Nucleoside Reverse Transcriptase Inhibitors (NRTI)Efavirenz-Tenofovir DF-Emtricitabine![Efavirenz-Tenofovir DF-Emtricitabine Atripla](https://cdn.hiv.uw.edu/css/images/drugs/40.png)
![Efavirenz-Tenofovir DF-Emtricitabine Atripla](https://cdn.hiv.uw.edu/css/images/drugs/40.png)
Efavirenz-Tenofovir DF-Emtricitabine
Tradename:AtriplaOther Names:EFV-TDF-FTC, Efavirenz-Tenofovir disoproxil fumarate-EmtricitabineClass:Single-Tablet RegimensCategories PharmacologyTreatment-ExperiencedSwitch/SimplificationAdverse Effects
Funding
IndustryGilead Sciences
References
- Fisher M, Moyle GJ, Shahmanesh M, et al. A randomized comparative trial of continued zidovudine/lamivudine or replacement with tenofovir disoproxil fumarate/emtricitabine in efavirenz-treated HIV-1-infected individuals. J Acquir Immune Defic Syndr. 2009;51:562-8.