A 23-year-old cisgender man with HIV and a recent CD4 count of 512 cells/mm3 is seen for evaluation of fever and rash. On examination, he is noted to have a diffuse macular rash on his trunk, extremities, and palms (Figure 1). He has sex with other men and is taking suppressive antiretroviral therapy. He reports no neurologic or ocular symptoms, and the neurologic examination is normal. Syphilis serologic studies are ordered. Testing for syphilis was negative 4 months previously. A presumptive diagnosis of secondary syphilis is made.
What would you recommend as the preferred treatment of syphilis in this individual?
Figure 1. Skin Rash on Palms
Photograph from David H. Spach, MD
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Question Last Updated
September 29th, 2023
September 29th, 2023
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